CYCS and cancer: As was shown by Zhang et al., SHP upon induction by the synthetic retinoid γ receptor agonist, AHPN (6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid) can be translocated from the nucleus into mitochondria, when it interacts with Bcl-2 protein, followed by disruption of the Bcl-2/Bid interaction and cytochrome c release in cancer cells.