SHMT1 and osteosarcoma: Based on our statistical analysis of the correlation between copy number increase and expression level for each of the top ranking genes, we identified RICH2, c17orf45, TOP3A, COPS3, SHMT1, PRPSAP2, PMP22, and RASD1 as candidate osteosarcoma oncogenes in the 17p11.2-p12 region (Table 2).