TGFBR1 and colorectal carcinoma: In the current work, we have presented evidence that individuals carrying the specific TGFBR1 H2 haplotype and TGFBR1 ASE have a high relative risk of CRC (RR = 5.250; 95% CI: 2.55–5.25), whereas the individual risk associated with each of these factors is negligible.