Surprisingly, although MMP was dramatically reduced in response to the co-expression of the three proteins (Figure 6A), we found neither of dead cells (Figure 6B and Figure S7), caspase-3 activation (Figure 6C), nor the cytochrome c release from mitochondria (Figure S8) in any of HCT116 and A549 cells from early phase (48 h after infection) to late phase (96 h after infection). Here, CASP3 is linked to infection.