As shown in Figure 5, the expression of either Mieap α or Mieap β alone through infection with Ad-Mieap α or Ad-Mieap β induced a slight decrease in MMP (M1: cont 11.6% and LacZ 11.5% vs Mieap α 24.7% and Mieap β 28.8%). The gene discussed is SPATA18; the disease is infection.