Three plasmid-associated phenotypes have been identified in C. muridarum and are conserved in C. trachomatis: plasmid-deficient strains are unable to accumulate glycogen within the intracellular inclusion during the developmental cycle, display reduced infectivity in vitro [3], and in vivo [4] and do not stimulate TLR2 signaling during infection [4]. The gene discussed is TLR2; the disease is infection.