Other data [7] proved that UCP2 expression in HCT116 human colon cancer cells decreased apoptosis induced by mechanisms involving modulation of p53 pathway, a pivotal tumor suppressor, but it still needs other experiments to prove whether UCP2 plays anti-apoptotic role by modulation of p53 pathway in hypoxia. The gene discussed is TP53; the disease is malignant colon neoplasm.