Given the observation that overexpression of ephrin-B2 in some tumors is correlated with poor prognosis [1], [16], it will be an interesting question if the role of ephrin-B2 together with EphB receptors in some tumor is associated with the promotion of the vasculature growth and the adenoma-carcinoma transition, facilitating tumor metastasis. This evidence concerns the gene EFNB2 and adenoma.