When colon tumor tissues were immunostained after tumor growth in mice and harvest, EC8 not only delineated human tumor xenograft with high ephrin-B2 expression, but also identified the vasculature within the tumor due to the cross-reactivity of EC8 with both human and murine ephrin-B2 (Fig. 3C). The gene discussed is EFNB2; the disease is colonic neoplasm.