Indeed, Lichy et al found a marked decrease in YY1 binding in malignant HeLa/fibroblast somatic cell hybrids when compared to non-tumor cells, [14] while Austen and colleagues showed that YY1 is a negative regulator of cell growth via potent inhibition of c-myc transforming activity and possible involvement in tumor suppression [15]. This evidence concerns the gene MYC and neoplasm.