Because a reduction in proliferation was found in the VZ and EGL but not in the regions of postmitotic neurons of BCCIP-CKD mice (Figure 5), and an increase of apoptosis was detected in highly proliferating regions of the neocortices and EGL of BCCIP-CKD mice (Figures 5C, 6, 7), we suggest that BCCIP plays its roles in neural-development by supporting proliferation of neural progenitors. Here, BCCIP is linked to chronic kidney disease.