GAD2 and ischemia: We therefore analyzed: i) if a combined treatment composed of spinal segment-specific upregulation of GAD65 (glutamate-decarboxylase) gene and systemic delivery of tiagabine (GABA uptake inhibitor) in rats with ischemia-induced spasticity will lead to an antispasticity effect, and ii) whether such a combined treatment will be specific for GAD65 gene overexpressing spinal segments.