NR1H4 and primary biliary cholangitis: While activation of FXR favours bile acid detoxification by hepatocytes and FXR ligands have been proposed in the treatment of PBC patients [1], results from models of obstructive cholestasis in FXR−/− mice have shown that FXR gene ablation protects against liver injury caused by ligation of common bile duct (BDL) [3].