Multivariable regression analysis has shown that IDH1 mutation is an independent prognostic factor in anaplastic oligodendroglial tumors when referring to type of surgery, KPS, age, location, the central histology review diagnosis, endothelial abnormalities, necrosis, and the molecular factors such as 1p/19q loss, EGFR amplification, and MGMT promoter methylation [25]. The gene discussed is EGFR; the disease is oligodendroglial tumor.