CYP17A1 and Parkinson disease: The latter approach highlighted diacylglycerol kinase, theta 110 kDa (DGKQ), a gene that has a strong association in patients of Dutch decent with familial [37] and sporadic [38] Parkinson's disease Inhibition of DGKQ activity attenuates the binding of SF1 to the CYP17 promoter, subsequently inhibiting cAMP-dependent CYP17 transcription.