Genetic studies using candidate gene-approaches, and recently, genome-wide association studies (GWAS), have uncovered more than 25 SLE susceptibility genes, including HLA-DRB1, IRF5, STAT4, ITGAM, BLK, TNFAIP3, and others [3]–[18]. This evidence concerns the gene STAT4 and systemic lupus erythematosus.