A different role of IFI16 in HCMV replication has been demonstrated by Cristea et al. [23], who identified the interaction of pUL83 (pp65) with IFI16 throughout the course of HCMV infection and showed that pUL83 recruits IFI16 to the major immediate-early promoter (MIEP) and stimulates, rather than inhibiting, MIEP activity. The gene discussed is IFI16; the disease is cytomegalovirus infection.