To investigate this hypothesis, the pUL54 0.15 construct and the pMIEP-Gl3 plasmid, a reporter plasmid in which the luciferase gene is driven by the HCMV major immediate-early promoter (MIEP), were transfected into HELFs that were then infected with either AdV IFI16 or AdV LacZ followed by HCMV infection. Here, IFI16 is linked to cytomegalovirus infection.