PLK2 and neoplasm: In clinical cases of EOC, DNA methylation of the CpG island in the PLK2 promoter in tumor tissue was associated with a higher risk of relapse in patients treated post-operatively with carboplatin and paclitaxel and this trend was also reflected in the analysis of matched serum samples in which detection of methylated PLK2 genomic DNA was more frequent in relapsed cases [9], Figure 1A.