Most recently, Wei et al. reported that plasma levels of the soluble urokinase plasminogen activating receptor (suPAR) are elevated above an apparent threshold level (>3 ng/mL) in about two thirds of steroid-resistant FSGS patients and that suPAR induces proteinuria 24 hours after infusion into mice [33]. This evidence concerns the gene PLAUR and focal segmental glomerulosclerosis.