As it was published by several groups that not only caspase-8 but also caspase-10 can be recruited to death receptors [50, 51], Apo2L/TRAIL is able to activate both initiator caspases, and caspase-10 is described as important caspase in HCT 116 colon carcinoma cells [52], we analysed the DISC formation in more detail. The gene discussed is TNFSF10; the disease is colon carcinoma.