Glycogen storage disease: An increased prevalence of autoimmune hypothyroidism has been found in type Ib glycogenosis (glucose-6-phospate translocase defect) (ORPHA79259); however, patients with the type Ia form (glucose-6 phosphatase defect) (ORPHA79258) had a low frequency of thyropathies in a series of patients with glycogenosis (10 with type 1a and 7 with type Ib) compared to 34 matched controls [49]. The gene discussed is G6PC1; the disease is disorder of glycogen metabolism.