GH1 and acute lymphoblastic leukemia: Gurney and colleagues, following up 75 long-term childhood ALL survivors from the Childhood Cancer Survivor Study (CCSS), demonstrated that 60% of subjects treated with cranial irradiation, compared with 20% of those who were not, had presented 2 or more components of MS and that untreated abnormally low GH levels were present in 85% of irradiated patients [44].