DACH1 and Familial prostate cancer: The prognostic value of DACH1 seems to be cancer-type dependent in that reduced DACH1 levels have been associated with poor prognosis in breast, gastric, and endometrial cancer [16,17,19] and with tumour progression in prostate cancer [15], whilst in EOC, DACH1 has been shown to be up-regulated in advance-stage ovarian cancer and promote resistance to TGF-β signaling [18].