CHEK1 and serous adenocarcinoma: However, the association between DACH2 expression and other investigative markers, e.g. Chek1, Chek2, MCM3 and Ki67, was only evident in the full cohort and not in the subgroup of serous carcinoma, where DACH2 expression was significantly higher than in non-serous carcinomas, and an independent factor of poor prognosis.