Studies of KAT80 and KAT60a in the related kinetoplastid, Leishmania major, suggest they may play a role in cytokinesis, since they relocalise to the cleavage furrow during cytokinesis [47], but to date, the only other evidence linking katanins with cytokinesis comes from studies of the LAPSER1 candidate tumour suppressor gene for prostate cancer in a rat cell line [63], [64]. The gene discussed is LZTS2; the disease is Familial prostate cancer.