The IT-treated mice also had marked reductions in lysosomal-associated membrane protein-1 (LAMP-1) immunoreactivity, a lysosomal protein marker used for the detection of lysosomal storage disorders and an indicator of disease state, in the surface cerebral cortex, caudate nucleus, thalamus, cerebellum and white matter (Figure 5B, a-j). Here, LAMP1 is linked to lysosomal storage disease.