In order to address the possibility that impaired renal function had a direct effect on Ang-2 levels, association of Ang-2 with GFR was measured not only among subjects at screening (median 60 ml/min/1.73 m2, interquartile range 36–79), but more importantly among subjects in remission at month 6 (median 61, interquartile range 41–74), so as to avoid active GN as a confounder. Here, ANGPT2 is linked to ganglioneuroma.