Similarly, in the current study, subjects with GN had higher Ang-2 levels than those without GN; subjects with newly-diagnosed AAV had higher levels than subjects with relapsing AAV; subjects who were untreated had higher levels than subjects already on an immune-suppressive drug at the time of screening; and untreated subjects with newly-diagnosed AAV had higher levels than subjects not meeting these criteria. This evidence concerns the gene ANGPT2 and ganglioneuroma.