For example, flavopiridol is seen to be connected to five different complexes associated to Parkinson disease, which are the RC S-phase, RC G2/M-phase, p16-cyclin D2-CDK4, CDK8-MED6-PARP1 and ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complexes (Figure 8). The gene discussed is ESR1; the disease is Parkinson disease.