STAT3 and cancer: Based on our findings that 14-3-3ζ and Stat3 act in concert in the maintenance of the MM signaling, it is worthwhile considering a more specific strategy that target Stat3/14-3-3ζ interaction, as such drugs may spare some of the essential homeostatic functions executed by 14-3-3ζ and Stat3 on their own, while inhibiting their malicious cooperation in cancer cells.