Interestingly, the single depletion of neither PDGFR-α nor PDGFR-β inhibited Mcl-1 expression in ARCaPM cells, suggesting that the PDGF-BB signal could be transduced via the two independent but complementary receptors to activate Mcl-1 expression in PCa cells expressing both isoforms. The gene discussed is PDGFRB; the disease is posterior cortical atrophy.