Interestingly, the single depletion of neither PDGFR-α nor PDGFR-β inhibited Mcl-1 expression in ARCaPM cells, suggesting that the PDGF-BB signal could be transduced via the two independent but complementary receptors to activate Mcl-1 expression in PCa cells expressing both isoforms. Here, MCL1 is linked to posterior cortical atrophy.