MCL1 and posterior cortical atrophy: For the first time, we demonstrated that: 1) PDGF-BB is a novel regulator of Mcl-1 expression; 2) PDGF-BB activation of autocrine PDGFR signaling promotes the interaction between β-catenin and HIF-1α, presumably through a c-Abl-p68-dependent mechanism; 3) a putative HRE motif is required for the basal expression and PDGF-BB activation of Mcl-1 promoter; and 4) inhibition of the PDGFR-Mcl-1 signaling using a small-molecule inhibitor AG-17 could activate apoptotic response in metastatic PCa cells.