Given the fact that both PDGFR-α and -β have been implicated in the progression of bone metastatic PCa [10], [12], [13], [45], [48], our study focused on the function of PDGF-BB since it is the only PDGF isoform that binds all the three receptor dimeric combinations (PDGFR-αα, -ββ and -αβ) with high affinity [2], [49]. Here, PDGFRA is linked to posterior cortical atrophy.