Consistently, using a human PCa ARCaP cellular model that could closely mimic the pathophysiology of bone metastasis in immunocompromised mice [26], we found that Mcl-1 expression was significantly increased in highly bone metastatic ARCaPM cells when compared to that in the low-invasive counterpart ARCaPE cells (Figure 1A). The gene discussed is MCL1; the disease is posterior cortical atrophy.