In addition, we demonstrate that the expansion of Treg cells in colorectal cancer patients was particularly prominent within the naïve CCR7+CD45RA+ CD4+CD25highFOXP3+ Treg cell population and to a lesser extent in central memory Treg cells, while there was no difference in Treg cells with an effector memory phenotype. The gene discussed is CD4; the disease is colorectal cancer.