HNF4A and cancer: In cancer cells, β-catenin, a key factor of the canonical Wnt signaling pathway, accumulates in the cytoplasm and then translocates into the nucleus to form a complex with the transcription factor Lef/TCF (Lef, lymphoid enhancer factor; TCF, T-cell factor protein), which subsequently activates Wnt-responsive genes, including cyclin D1 [1].