We hope, that with additional elucidation of the Wnt pathway and the roles of p120ctn isoforms in carcinogenesis, particularly in the development of lung cancer, certain pharmacologic or antibody-based therapeutic agents could be designed to target the key mediators in the Wnt pathway in order to circumvent the side effects of conventional chemotherapy currently used and, ultimately, improve the survival and quality of life for lung cancer patients. The gene discussed is CTNND1; the disease is lung carcinoma.