We have demonstrated that activation of JNK is playing an apoptotic role in MM cells induced by RITA, which is consistent with a previous observation showing the requirement of JNK activation JNK for the stabilization of p53 and enhancement of p53 trans-activation by abrogating MDM2 association in p53 null fibroblast [15]. The gene discussed is MAPK8; the disease is Miyoshi myopathy.