During sepsis, lipopolysaccharide (LPS), which is derived from the cell wall of gram-negative bacteria, can induce the expression of inflammatory mediators and cytokines such as TNF-α, interleukin-6 (IL-6), interleukin-1β (IL-1β), and interleukin-10 (IL-10), as well as lead to the release of nitric oxide (NO). The gene discussed is IL10; the disease is Sepsis.