There are 6 genes that are conserved between human and mouse in the Lipi-Usp25 region: Lipi, Rbm11, Hspa13, Samsn1, Nrip1 and Usp25. To investigate potential molecular mechanisms leading to HFD-induced obesity in monosomic Ms1Dja mice, we performed qRT-PCR analysis on all the genes from the deleted interval in adipocytes from monosomic and wildtype littermates. Here, SAMSN1 is linked to obesity due to melanocortin 4 receptor deficiency.