Although the role of genetic factors, including polymorphisms in the BRCA1, BRCA2, ATM, CHEK2, p53, PTEN, NBS1, RAD50, BRIP1, and PALB2 genes have been extensively studied in breast cancer in EA populations [3], there are few studies of the role of common variants in nuclear gene(s) related to mitochondrial function in the etiology of breast cancer in AA women. The gene discussed is PTEN; the disease is breast carcinoma.