When activated by its ligand, high mobility group box 1 (HMGB1) [14], [15], RAGE transduces a promyogenic and anti-proliferative and anti-tumor signal in cells of the myogenic lineage [12], [16], [17], and deletion of Rage results in delayed regeneration following injury, elevated satellite cell numbers, reduced myofiber numbers and myofiber hypertrophy [13]. The gene discussed is HMGB1; the disease is neoplasm.