EGFR has been linked to many common cancers, including head and neck cancer, colorectal cancer (CRC), pancreatic cancer, and non-small-cell lung cancer (NSCLC), and overproduction of EGFR is associated with more aggressive clinical behavior (including more tumor angiogenesis, proliferation, and metastasis) and shorter overall survival time [2–4]. This evidence concerns the gene EGFR and head and neck cancer.