However, other factors may explain this finding; (I) patients with TN tumours present at a younger age than other subtypes [11], (II) the frequency of HER-2 over-expression decreases with increasing age at diagnosis [14] although this may not be a unanimous finding as some data show HER-2 over-expression not significantly different in women <35 and >=35 years [15], (III) women in Saudi Arabia present with breast cancer at younger age. This evidence concerns the gene ERBB2 and breast cancer.