SERPINC1 and coronary artery disorder: To provide insight into the effects of fenretinide and the different routes of HRT administration on biomarkers of CHD risk, we investigated in a randomized trial the changes in lipids and clotting profiles, including total cholesterol high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides antithrombin III (AT-III), fibrinogen platelets and PAI-1, after 12 months of transdermal E2, oral CEE and fenretinide or placebo.