The C1q domain present in CTRP5 is known to strongly interact with the complement C1r/C1s, Uegf, Bmp1 (CUB) domains joined by LDLa (together known as the CUBT domain) in MFRP. Mutations in MFRP are reported to cause an autosomal recessive syndrome of nanophthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen in human subjects and retinal degeneration in the rd6 mouse model [10,14]. Here, MFRP is linked to microphthalmia.