TP53 and carcinoma: It may be that the E6 protein of HPV16 is more efficient in inactivation of p53 at the posttranslational level than E6 of HPV31 and that for this type additional events are needed to inactivate p53. Indeed, the study of Ku et al. reported that in cervical carcinomas the majority of cases with p53 mutations and LOH at 17p occurred in carcinomas harbouring types other than HPV16 [63].