First, for control HCVpp infections, cells were infected with pseudotyped lentiviruses encoding a luciferase reporter and bearing the glycoproteins E1 and E2 of HCV genotype 2a (JFHpp), HCV E1 and E2 of genotype 1a (H77pp) or the VSV G glycoprotein (VSVGpp). This evidence concerns the gene ART4 and infection.