However, changes in expression of genes involved in the incorporation of fatty acids have also been observed in young, pre-hypertensive SHR, and particularly a decreased expression of a gene responsible for the synthesis of long-chain fatty acyl-CoAs (Acyl-CoA long-chain family member 3, Acsl3), suggesting that these differences in gene expression are hypertension-independent. Here, ACSL3 is linked to Hypertension.