Benoit et al. [18] found a correlation between COX2 expression and TP53 wild-type status in esophageal adenocarcinoma with Barrett's esophagus as a precursor lesion, but not in SCC, providing evidence that the participation of p53 in the regulation of COX2 expression in cancer may be dependent on tumor histology. The gene discussed is TP53; the disease is neoplasm.