Receiver operating characteristic curve analysis revealed that IRAK3 (mean AUC, 95%CI: 0.63, 0.54–0.72, P<0.05), TNFAIP3 (0.65, 0.56–0.73, P<0.01), SOD2 (0.69, 0.60–0.77, P<0.001), and TNFα (0.71, 0.62–0.78, P<0.001) were associated with metabolic syndrome. The gene discussed is TNFAIP3; the disease is metabolic syndrome.