EZH2 and prostate cancer: However, EZH2 knockdown significantly decreased invasiveness of the prostate cancer cells (Figure 1C, middle); only 18∼20% of the prostate cancer cells infected with lentivirus expressing EZH2 targeting shRNA penetrated the BME membrane in the chamber (sh1 and sh2), compared with those cells infected with the control (NT, nontargeting shRNA) lentivirus (Figure 1C, bottom).