Early studies showed that high levels of EZH2 expression are associated with invasion and metastasis of malignant tumors such as breast and prostate cancers [27]–[31] and that EZH2 overexpression transforms the benign prostate cells RWPE-1 [32] and BPH1 [33] and the immortalized breast epithelial cells [28]. This evidence concerns the gene EZH2 and cancer.