RGS5 deficiency would likely involve enhanced Gαi-mediated signal pathway and be in charge of increased lipogenesis (mediated by DGAT1, DGAT2 and GPAT1) and decreased lipolysis (mediated by HSL and ATGL), under the conditions of hyperinsulinemia and high FFA, which can induce adipocyte hypertrophy [18], [19], [20]. Here, PNPLA2 is linked to hyperinsulinism.