Functional diversity may exist among RGS proteins and RGS5 is an important member of the RGS protein superfamily that has recently been reported to regulate cardiac hypertrophy, atherosclerosis and angiogenesis through the inhibition of several Gαi- and Gαq-mediated signaling pathways [10], [11], [12], [13]. Here, PITX2 is linked to hypertrophy.