As a PrP interacting partner, the polymerization of tubulin and the cellular microtubule structures can be impaired directly via interacting with a couple of CJD-associated PrP mutants [16], [18], or indirectly via influencing on other microtubule associated proteins, such as tau [32] and TPPP [33]. Here, PRNP is linked to Creutzfeldt Jacob disease.