PARP1 and neoplasm: We set out to analyze Scutellaria flavonoids in a number of assays designed to ascertain whether one or more of the compounds have the following activities determined for Bezielle: (a), induction of ROS, particularly of mitochondrial superoxide; (b) increase in ROS levels over time; (c) induction of oxidative stress induced selective tumor cell death; (d), dependence of cell death induction on presence of respiring mitochondria; (e), induction of DNA damage and hyper-activation of PARP; (f), disruption of cellular redox status; (g), inhibition of both cellular energy-producing pathways.