As NGF prevents apoptosis through TrkA by increasing expression of the anti-apoptotic Bcl-2 family members, whereas p75NTR signaling promotes apoptosis via JNK, NF-κB and ceramide activation, these adjustments are geared to keep the infected airway epithelial cells alive to support RSV replication and infection with a mechanism similar to that previously described in macrophages infected with the human immunodeficiency virus (HIV) [4]. The gene discussed is NGF; the disease is infection.