For example, in rhodopsin the non-synonymous (ns) SNP A164V4.53 destabilizes helix packing resulting in protein misfolding and causes retinitis pigmentosa [23], similarly the T164I4.56 nsSNP in β2-AR is hypofunctional and is associated with coronary and peripheral artery disease [24]. This evidence concerns the gene RHO and retinitis pigmentosa.