Studies on the isolated hearts from HspB2 knockout mice have shown an impaired regeneration of ATP and phosphocreatine during recovery after ischemia, indicating its central role in cardiac energetics during ischemia/reperfusion; further knockout mice that were administered dobutamine (a strong inotropic and positive chronotropic) stimulus showed that HspB2 allows for a greater capacity for increased work during acute inotropic challenge [38]. Here, HSPB2 is linked to ischemia.